3B). R526 from the loop among ?J and ?I anchors the C-terminal portion of the activation loop by forming a salt bridge with E458 at The bottom of ?EF. Q459 stabilizes the HRD motif by a hydrogen bond to the leading chain carbonyl of R413. The tip from the activation section is stabilized by a hydrogen bond among Y454 and E480 from ?F. within the FT… Read More